MOTS-c (10mg)

MOTS-c (10mg)

MOTS-c (10mg)

$73.00
$73.00
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What is MOTS‑c?

Mitochondrial Open Reading Frame of the 12S rRNA type‑c (MOTS‑c) is a 16‑amino‑acid peptide encoded within the mitochondrial 12S rRNA gene. Classified as a mitochondrial-derived peptide (MDP), MOTS‑c is released in response to metabolic or exercise stress and translocates to the nucleus, where it modulates gene expression related to stress adaptation, energy balance, and mitochondrial function.

Chemical Structure of MOTS‑c

MOTS‑c consists of the 16‑amino acid sequence Met–Arg–Trp–Gln–Glu–Met–Gly–Tyr–Ile–Phe–Tyr–Pro–Arg–Lys–Leu–Arg, with a molecular formula of C₁₀₁H₁₅₂N₂₈O₂₂S₂ and a molecular weight of approximately 2,174.6 Da, as listed in PubChem (CID 255386757). Also known as the 12S rRF‑encoded mitochondrial peptide, MOTS‑c is conserved across human mitochondrial DNA.

What Are the Effects of MOTS‑c?

  • Energy and Metabolic Regulation: MOTS‑c activates the AICAR–AMPK pathway, increasing endogenous AICAR and enhancing energy expenditure, glucose utilization, and fatty acid oxidation in rodent models.
  • Insulin Sensitivity: In high-fat-fed mice, MOTS‑c improved insulin responsiveness and glucose tolerance compared to controls.
  • Muscle Endurance: Animal studies demonstrate enhanced mitochondrial performance, endurance capacity, and physical activity when MOTS‑c is combined with exercise.
  • Cardiovascular Support: By activating AMPK, MOTS‑c reduces vascular calcification and restores mitochondrial function in heart tissue.
  • Longevity‑Related Benefits: Endogenous MOTS‑c decreases with age; long-term administration in aged mice enhances metabolic resilience, improves fitness, and promotes healthspan.