Melanotan-2 (MT-2) (10mg)

Melanotan-2 (MT-2) (10mg)

Melanotan-2 (MT-2) (10mg)

$50.00
$50.00
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What is MT‑II (Melanotan II)?

MT‑II, also known as Melanotan II, is a synthetic cyclic peptide analogue of the natural hormone α‑melanocyte-stimulating hormone (α‑MSH). It acts as a non-selective melanocortin receptor agonist, binding primarily to MC₁R, MC₃R, MC₄R, and MC₅R. This structural mimicry of α‑MSH allows MT‑II to be a key research tool for exploring pigmentation, energy balance, and neuroendocrine signaling pathways.

Chemical Structure of MT‑II (Melanotan II)

MT‑II is a synthetic heptapeptide with the sequence Ac‑Nle‑cyclo[Asp‑His‑D‑Phe‑Arg‑Trp‑Lys]‑NH₂. The peptide is stabilized through a lactam bridge between Asp and Lys, forming a cyclic structure that enhances receptor binding and metabolic stability. MT‑II has a molecular formula of C₅₀H₆₉N₁₅O₉ and an approximate molecular weight of 1,024.2 Da. It is listed in PubChem under CID 92432.

What Are the Effects of MT‑II (Melanotan II)?

  • Pigmentation Research: MT‑II activates MC₁R, leading to increased eumelanin production and pigmentation in laboratory models.
  • Appetite and Metabolic Studies: Through MC₃R and MC₄R activation, MT‑II has been studied for its appetite-suppressing and energy-regulating effects.
  • Tumor Suppression Research: Experimental models show MT‑II can reduce melanoma cell proliferation and tumor invasiveness by influencing PTEN and NF‑κB signaling.
  • Behavioral Research: MT‑II has been reported to modulate neuroendocrine and sexual behavior pathways in preclinical studies, linked to its MC₄R activity.